Prostate Cancer Research Scientific Abstracts - A
Welcome to the Prostate Cancer Guide scientific abstracts, author section A. Here you will find abstracts from the latest cancer research being carried out in the field.
This section is recommended for people who have a scientific interest in prostate cancer research. It is recommended that people without prior knowledge of prostate cancer visit the more general areas of the site (Prostate Cancer Guide).
Abstract Authors
Aabo K., Aalamian M., Aaltomaa S., Aarnink R.G.,
Latest Prostate Cancer Abstract
Journal:Mollecular and Cellular Biochemistry
Pubmed ID: 16691315
- Authors: Arunkumar A, Vijayababu MR, Srinivasan N, Aruldhas MM, Arunakaran J.
Title: Garlic Compound, Diallyl Disulfide Induces Cell Cycle Arrest in Prostate Cancer Cell Line PC-3.
Prostate cancer is the most predominant cancer in men and related death rate increases every year. Till date, there is no effective therapy for androgen independent prostate cancer. Previous studies reported that aged garlic extract suppresses cancer growth. In the present study, diallyl disulfide, oil soluble organosulfur compound of garlic, was studied for its antiproliferative and induction of cell cycle arrest on prostate cancer cells in vitro. The suppression of cell growth was assessed by MTT assay. Induction of cell cycle arrest was assessed and confirmed by propidium iodide staining in flowcytometric analysis and western blotting analysis of major cell cycle regulator proteins. The results showed that diallyl disulfide inhibited the growth of prostate cancer cells in a dose dependent manner, compared to the control. At 25 muM and 40 muM concentrations, diallyl disulfideinduced cell cycle arrest at G2/M transition in PC-3 cells. Western blotting analysis of cyclin A, B(1) and cyclin dependent kinase 1 revealed that diallyl disulfide inhibited the cell cycle by downregulating cyclin dependent kinase 1 expression. It is concluded that diallyl disulfide, inhibits proliferation of prostate cancer cells through cell cycle arrest. Dose dependent effect of diallyl disulfide on PC-3 cell line was observed in the present study.
Contact: Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, 600 113, India, j_arunakaran@hotmail.com.