Prostate Cancer Scientific Abstracts - R. Daher

Welcome to the Prostate Cancer Guide scientific abstracts, author section R. Daher.

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Selected R Daher prostate cancer abstracts

Journal: Clinical chemistry and laboratory medicine

Pubmed ID: 9804390

Authors: Daher R, Beaini M.

Title: Prostate-specific antigen and new related markers for prostate cancer.
Although prostate-specific antigen (PSA), or human kallikrein 3, is the most valuable tool available for the diagnosis and management of prostate cancer, as currently used it is insufficiently sensitive and specific for early detection or staging of the malignancy. Many new concepts have been introduced in order to optimize the clinical use of prostate-specific antigen measurements, but each one has its own drawbacks. The molecular forms of prostate-specific antigen, especially the free prostate-specific antigen, seem to be useful for the detection of prostate cancer in men with prostate-specific antigen concentrations falling in the 4-10 microg/l range. New molecular techniques, such as reverse transcriptase polymerase chain reaction for the detection of minimal amounts of prostate-specific antigen messenger RNA and prostate-specific membrane antigen, offer new promise for the prognosis and possibly staging of prostate cancer. On the other hand, human kallikrein 2, a serine protease closely related to prostate-specific antigen that is also expressed predominantly in the prostate, may be a new adjuvant marker for prostate cancer. As for its biological functions, prostate-specific antigen can no longer be regarded as a specific prostate molecule associated mainly with semen liquefaction when it has a possible role as a prognostic indicator in female breast cancer. The biological role of prostate-specific antigen in normal tissues and tumors may be much more complex than previously thought and requires further investigation.

Contact: Department of Pathology and Laboratory Medicine, American University of Beirut, Lebanon.

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